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KMID : 0371619910070010049
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Journal of Wonkwang Medical Science
1991 Volume.7 No. 1 p.49 ~ p.58
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Morphometric analysis of rat thyroid gland after administration of iodide and propylthiouracil
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Choi, Chan/최찬
Park, Seung Woong/Kim, Eun Cheol/Moon, Hyung Bae/박성웅/김은철/문형배
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Abstract
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1
The effects of iodide and propylthiouracil on the follicles of thyroid were investigated in Sprague-Dawley rats. Either one ml of Lugol´s solution (2.5%, 5% ) or propylthiouracil (125 mg, 2.5 mg) was administered orally twice a day. The rats were killed by cervical dislocation at 8 days, 1 week, 2 weeks, 3 weeks and 4 weeks after initiation of administration. The morphologic parameters measured were : follicle area (FA), lumen area (LA), follicular epithelial cell area (FCA ; FA - LA) and cellularity index (CI : FCA/FA x 100). When Lugol´s solution was administered, the thyroid gland became hypocellular, but it returned to normal after 3 or 4 weeks. The change of cellularity varies with dosage of Lugol´s solution and duration of administration. When propylthiouracil was administered, the thyroid initially became hypercellular, but soon became normocellular and finally hypercellular. In Lugol´s solution-administered groups, FA correlated well with LA in all experimental groups. It correlated poorly with FCA in Lugol´s solution-administered groups, although it correlated well in propylthiouracil-administered groups.
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